Autism, better known today as autism spectrum disorders (ASD), is a pervasive
development disorder (PDD), all of which are characterized by varying degrees of
impairment in communication skills, social interactions, and restricted, repetitive and
stereotyped patterns of behavior. Autism spectrum disorders range from a severe form,
called autistic disorder, to a milder form, known as Asperger syndrome. If a child has
symptoms of either of these disorders, but does not meet the specific criteria for either,
the diagnosis is called pervasive developmental disorder not otherwise specified
(PPD-NOS). Other rare, but very severe disorders that are included in the autism
spectrum disorders are Rett syndrome and childhood disintegrative disorder.
The autism spectrum disorders are more common in the pediatric population than some
better-known diseases, like diabetes, spinal bifida or Down syndrome. A recent study in
the United States estimated that 3.4 of every 1,000 children 3-10 years of age has autism.
Males are four times more likely to have autism than females.
The hallmark feature of autism is impaired social interaction. As early as infancy, a baby
with autism may be unresponsive to people or focus intently on one item, to the exclusion
of others, for long periods of time. Some affected children appear to develop normally and
then withdraw and become indifferent to social engagement. Children with autism also
usually fail to respond to their name and often avoid eye contact with other people.
Many children with autism engage in repetitive movements, such as rocking and twirling,
or in self-abusive behavior, like biting or headbanging. They also tend to start speaking
later than other children and may refer to themselves by name instead of “I” or “me”. Some
affected children speak in a sing-song voice about a narrow range of favorite topics, with
little regard for the interests of the person to whom they are speaking. In addition, they
ordinarily do not know how to play inter-actively with other children. Children with autism
spectrum disorders also have a reduced sensitivity to pain, but are abnormally sensitive
to sound, touch or other sensory stimulations. Some sounds – a vacuum cleaner, a ringing
telephone or a sudden storm – can cause some of the children to cover their ears and
scream. Many of the affected children find the feel of clothes touching their skin to be
unbearable. These unusual reactions may contribute to behavioral symptoms, such as
resistance to being hugged or cuddled.
The most severe forms of autism spectrum disorders are Rett syndrome and childhood
disintegrative disorder. Rett syndrome almost exclusively occurs in females, with the
frequency being one per 10,000 to 15,000. After a period of development, usually
between 6 and 18 months, the child’s mental and social development regress – she no
longer responds to her parents and pulls away from any social contact. If she has been
talking, she stops; she cannot control her feet; and she wrings her hands.
Fewer than two children per 10,000 with autism spectrum disorders would be classified
as having childhood disintegrative disorder. Males are predominately affected and,
although symptoms can appear by the age of 2, the average age of onset is between 3
and 4 years. Until this time, the child usually has normal age-appropriate skills in
communication and social relationships. The loss of vocabulary, motor, language and
social skills is often dramatic and is accompanied by the loss of bowel and bladder
control and, frequently, seizures and very low IQ.
In addition to the behavioral and social impairments, children with autism spectrum
disorders often have one or more of the following associated complications.
- Mental retardation. Some areas of ability may be normal, while others may be especially
- Seizures. One in four affected children develops seizures, often starting in early
childhood or adolescence.
- Fragile X syndrome. A defective segment of the X chromosome is the most common
form of inherited mental retardation and affects 2-5% of individuals with autism spectrum
- Tuberous Sclerosis. 1-5% of individuals with autism spectrum disorders have tuberous
sclerosis, a rare genetic disorder that causes benign tumors to grow in the brain and
other vital organs.
Recognition of autism as a medical syndrome more than 50 years ago led to a search for
causative risk factors. Various research organizations came to the conclusion that
mercury poisoning due to the use of thimerosal, a
mercury-based preservative, in childhood vaccines was the responsible agent.
Thimerosal was never used as a preservative in some childhood vaccines (measles,
mumps, polio) and was removed from others (DPT)
several years ago. Despite the fact that no childhood vaccines have contained thimerosal
for several years, the incidence of autism rose from 0.3 per 1,000 births in 1993, to 1.5
per 1,000 births in 2003; to current
estimates of 3.4 per 1,000 births.
It is now believed that genetics and the environment both play a role Recent studies
strongly suggest that some people have a genetic predisposition to autism. In families
with one autistic child, the risk of having a second child with the disorder is approximately
5%, which is greater than the risk for the general population. A number of genes linked to
the disorder have been identified. A recent study at the University of Chicago identified a
micro-deletion on a particular chromosome in affected families. The micro-deletion
represented the loss of about 25 known genes, with 12 of them being part of a single
genetic network that includes genes involved in cell-to-cell signaling and interaction. At
least three of these genes are primarily expressed in the brain and are thought to
influence behavior. Studies at other institutions have identified micro-deletions on other
chromosomes with similar consequences in affected families.
Other studies of people with autism spectrum disorders have found irregularities in
several regions of the brain. It has also been shown that affected individuals have
abnormal levels of certain chemical neurotransmitters, like serotonin and glutathione, in
the brain. The combined abnormalities suggest that autism spectrum disorders could
result from early disruption of brain development in the fetus caused by defects in genes
that control brain growth and that regulate how neurons communicate with each other. It is
possible that sudden, rapid head growth may be an early warning signal that will lead to
early diagnosis and intervention. An effective treatment program requires early
intervention that focuses on behavioral management to reinforce desirable behaviors and
reduce undesirable ones. The most effective programs have strong parental involvement
and build on the child’s interests, offering a predictable schedule, teach tasks as a series
of simple steps, actively engage the child’s
attention in highly structured activities and provide regular reinforcement of behavior.
The life of an individual with an autism spectrum disorder can often be further complicated
by allergic reactions to various foods. At one time, it was believed that such allergic
reactions, particularly to gluten and certain proteins found in dairy products, were the
cause of the disorders. As a consequence, specialized diets were developed and falsely
touted as “cures” for the disorders. A further complication can be frequent occurrences of
gastrointestinal infections with organisms that are part of the natural flora, particularly
yeast (Candida species). These issues appear to indicate that the immune system may
also be compromised in some, if not all, individuals with autism spectrum disorders.
The Benefits of Bovine Colostrum
Colostrum is an amazing material that, like many other things in nature, reflects the
evolutionary development of a unique composition that will serve the needs of the
offspring for which it is intended. The most unique of the colostrums from mammalian
species occurs in bovines, where transfer of biological substances across the placenta to
the developing fetus does not occur and everything required for the development of a
healthy, productive offspring is provided in the colostrum. As such, bovine colostrum
provides a specialized resource that offers the broadest possible spectrum of biologically
active substances that can promote the development of a sound body mass, assure
effective and efficient metabolism and support the activation and maintenance of a fully
functional immune system capable of combating potential insults from microorganisms
and other deleterious sources. Bovine colostrum is also compatible with almost any
species and can readily convey its full benefits to humans by routine dietary
supplementation without any significant adverse effects.
The active substances found in high quality first milking bovine colostrum may
afford significant benefits to individuals with autism spectrum disorders.
In addition to its role as a neurotransmitter, glutathione is the most significant antioxidant
produced by a cell. It participates directly in the neutralization of free radicals and reactive
oxygen compounds and maintains other antioxidants, such as vitamins C and E, in their
active forms. In addition, glutathione can interact with many organic and inorganic
substances and assist the body in detoxifying them. When glutathione is ingested by
mouth, absorption into the body is negligible and, thus, it must be manufactured inside of
the cell. It is a tripeptide made up of three amino acids, cysteine, glycine and glutamic
acid. Both glycine and glutamic acid are readily available in the diet of most individuals,
but cysteine is not, making it the rate-limiting substance for glutathione formation within a
cell. As the free amino acid, cysteine is potentially toxic and is broken down in the
gastrointestinal tract and the
blood. The most stable form of this amino acid is as cystine, which is two cysteine
molecules linked together by a disulfide bond. Cystine is not broken down by stomach
acid or proteolytic enzymes and is readily absorbed. It is rapidly reduced to two cysteine
molecules when it enters a cell. In addition, cystine can cross the blood/brain barrier.
The proteins albumin, lactoferrin and lactalbumin found in substantial amounts in first
milking bovine colostrum are excellent resources for cystine. The amount of albumin is
highest in first milking colostrum and diminishes with time after birth. Transitional milk,
obtained at 96 hours (4 days) after birth of the calf, contains only about 20% of the
albumin found in first milking bovine colostrum taken within 6 hours after birth. Thus, first
milking bovine colostrum, obtained within 6 hours after the birth of a calf, contains
approximately 5x more albumin than milk and, therefore,
contributes at least 5x more cystine from albumin than milk.
The immunoglobulins IgG, IgM and IgA are complex proteins, better known as antibodies
that make up a significant portion of the proteins found in complete first milking bovine
colostrum. These antibodies were produced by the mother's immune system in response
to her exposure to many different microorganisms during her lifetime and then transferred
into the colostrum prior to birth of the calf. There is no evidence that any of these
antibodies are found intact in the blood of individuals who ingest colostrum by mouth.
However, many of these antibodies are reactive against bacteria, viruses and fungi,
including Candida species, that infect the gastrointestinal tract of humans and there is
scientific evidence that they can survive passage through the digestive system.
Immune System Deficiency
Very early in life, the foundation of the immune system is established within a small
gland-like structure in the upper chest, the thymus. It is within this structure that cells
mature that will determine the appropriate type of response that the immune system
should mount after an insult, whether from an invading microorganism or via an allergen.
Cells from the thymus will also regulate the quality and intensity of that response.
Scientific studies have shown that insulin-like growth factor (IGF-1), a major component of
high quality bovine colostrum, and the IGF superfamily of proteins can restore and
maintain a fully functional thymus, even in adults. In addition, colostrum contains the alpha
and beta chains of the hormone thymosin that act independently and in concert to regulate
the functions of the thymus and, therefore, are responsible for the activation, development
and maintenance of the immune system. Further, the prolinerich peptide (PRP), also
known as thymulin, in bovine colostrum is known to down-regulate the immune system and
keep the response to a foreign substance under control. Other studies have shown that
including only small amounts of colostrum in the daily diet of adult animals significantly
enhances the ability of their white blood cells to respond to infection and destroy invading
Colostrum is an amazing resource of substances necessary to strengthen and support the
immune system, potentiate the development and repair of cells and tissues; and assure
the effective and efficient metabolism of nutrients. However, it is very important to
recognize that all colostrum products are not the same and, despite the claims made by
their manufacturers, they do not all contain every beneficial component at an optimum
concentration. In many cases, they have been manipulated and may be missing some of
the essential components. When choosing a colostrum product, one needs to be certain
that it is made from only first milking bovine colostrum collected within 6 hours after birth of
the calf and that the colostrum is "complete" and that none of the components have been
removed, including the fat.
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Dr. Alfred E. Fox holds a Ph.D. from Rutgers University in Microbiology (Immunochemistry) and has more than 25 years of senior
management experience at Carter-Wallace, Baxter Dade Division and Warner-Lambert,
where he was responsible for research and development and regulatory affairs. He was also the founder and president of
two biotechnology companies focused on agribusiness and environmental monitoring, respectively. For the past 20 years, Dr.
Fox has been the President of Fox Associates, a business and technology consulting firm serving small- to mid-size companies
in the human and animal healthcare fields. He focuses primarily on marketing and regulatory issues and for the past 10+ years
has continuously consulted to bovine colostrum manufacturers, where he has gained regulatory approval for their products,
been a technical advisor, helped design and develop marketing strategies and served as an expert witness in legal matters.
Only Immune Tree Colostrum is Colostrum rich bovine first milk.
Cornel Professor Emeritus, Dr. Donald H. Lein
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