Idiopathic inflammatory bowel disease consists of Crohn's disease and ulcerative colitis.
Crohn's disease can affect any part of the gastrointestinal tract, from the mouth to the anus, and is known as
regional enteritis, terminal ileitis, or granulomatous colitis. Ulcerative colitis is limited to the colon and rectal
involvement is present 95% of the time. It has long been known that the development of Crohn's disease
somehow involves infection with Mycobacterium paratuberculosis, a relative of the bacterium that causes
tuberculosis. Researchers originally believed that it was the primary cause of the disease, but now recognize
that there are autoimmune manifestations associated with the disease and know that disease development is
much more complicated than originally believed.
There are many different levels of disease manifestation, but most people with the disease experience
gastrointestinal distress due to bowel inflammation, persistent diarrhea and wasting associated with
diminished nutritional uptake. These individuals are also much more susceptible than normal to enteric (gut)
Routine utilization of very high quality bovine colostrum, such as that distributed by Immune-Tree, would be
very advantageous to affected individuals for a number of reasons.
1. Insulin-like growth factor-1 (IGF-1) is a hormone-like substance found in colostrum. IGF-1 is the triggering
substance for a whole superfamily of 87 proteins that control most of the processes in every cell in the body.
One of the major functions is regulation of the metabolic pathway by which the body converts glucose (sugar)
to glycogen. Glycogen is stored in the muscles and the liver and is the main source of energy when the
muscles are exercised. Another major function of IGF-1 and the superfamily is regulating how cells use amino
acids to build proteins. Having sufficient IGF-1 available is extremely important in metabolically compromised
individuals and is essential to reversing the wasting aspects of the disease.
2. Another function of the IGF superfamily is the repair of damaged cells. Most of the proteins in the
superfamily are present in almost every cell in the body, but require activation and direction by the attachment
of IGF-1 to specific sites on a cell's surface. Again, having sufficient IGF-1 available is critical to affect cell
3. Colostrum also contains a number of gut protective factors that can act in concert to control enteric
infections. Some of the most important ones are:
a) The IgA immunoglobulins directed against various bacteria and viruses, like E. coli, Staph. aureus, etc.,
that can attack the gut and, more particularly, weakened tissue. IgA will not only attach itself to a
microorganism, but can also attach itself to tissue and immobilize the invading agent, letting other factors act
to destroy it.
b) Lactoferrin and transferrin are iron-binding proteins. Certain bacteria and some viruses that invade the gut
require iron to reproduce and, when this substance is withheld, they will die.
c) Lysozyme and lactoperoxidase are powerful enzymes that can attach to bacteria and eat holes through
their outer wall.
4. One of the problems is making sure that a substantial portion of these biologically active
substances gets through the stomach and into the intestines where they are needed. This is
accomplished by using complete first milking colostrum that contains all of the fat and casein, like
the colostrum products distributed by Immune-Tree. Although some manufacturers say that the fat
and casein have no role in colostrum, that is utter nonsense. The human stomach contains an
enzyme, rennin, that is also found in bovines and other species. Rennin acts on the fat and casein
in dairy products to form a soft cheese-like curd that protects the biologically active substances
against the enzymes and acid environment of the stomach, allowing the substances to either pass
through within the curd as it disintegrates and/or to be absorbed into the circulation.
To your good health - always.
Alfred E. Fox, Ph.D.
Colostrum heals the gastrointestinal tract, as it has skin growth hormones in it. Today, way too
many people have gastrointestinal permeability problems, which can lead not only to digestive issues
like colitis, diverticulitis, or leaky gut syndrome, but also allergies and conditions like diabetes. There
are no other substances on earth that can heal gastrointestinal permeability like colostrum can.
Therefore, it should be added to the leaky gut syndrome diet or supplement regime for gastrointestinal
The colostrum will also remove diseased bacteria from the gut. It keeps viruses from entering our cells
in the first place. There are actually a long list of diseases that colostrum has shown to heal. Further, it
has even been shown to build up lean muscle mass as well. As a result, many world-class athletes take
Once you start thinking about colostrum, it is clear that it is the most important food in the world. It is
also the most complete food on earth. After all, it is the first food that most people have been given. You
can rebuild your digestive system rapidly and effectively when you take colostrum and probiotics
Taken from: http://holisticgastroenterology.com/category/leaky-gut-syndrome
Co-administration of the health food supplement, bovine colostrum, reduces the acute
non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.
Clin Sci. 2001.
Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal
injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine
colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in
rats and mice. We therefore examined whether spray-dried, colostrum could reduce the rise in gut
permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients
taking NSAIDs for clinical reasons.
Healthy male volunteers (n=7) participated in a randomized crossover trial comparing changes in gut
permeability (lactulose/rhamnose ratios) before and after 5 days of 50 mg of indomethacin three times
daily (tds) per oral with colostrum (125 ml, tds) or whey protein (control) co-administration. A second
study examined the effect of colostral and control solutions (125 ml, tds for 7 days) on gut permeability
in patients (n=15) taking a substantial, regular dose of an NSAID for clinical reasons. For both studies,
there was a 2 week washout period between treatment arms. In volunteers, indomethacin caused a
3-fold increase in gut permeability in the control arm (lactulose/rhamnose ratio 0.36+/-0.07
prior to indomethacin and 1.17+/-0.25 on day 5, P<0.01), whereas no significant increase in
permeability was seen when colostrum was co-administered. In patients taking long-term NSAID
treatment, initial permeability ratios were low (0.13+/-0.02), despite continuing on the drug, and
permeability was not influenced by co-administration of test solutions. These studies provide
preliminary evidence that bovine colostrum, which is already currently available as an
over-the-counter preparation, may provide a novel approach to the prevention of
NSAID-induced gastrointestinal damage in humans.
Only Immune Tree Colostrum is Colostrum rich bovine first milk.
Cornel Professor Emeritus, Dr. Donald H. Lein
by Dr. Alfred E. Fox
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As colostrum becomes a more popular
treatment for intestinal permeability
(leaky gut syndrome) and irritable bowel
syndrome (IBS), information about the
supplement's immune factors and
benefits have become more
widespread. Donald Henderson, M.D.,
M.P.H., a gastroenterologist and chief of
staff at Daniel Freeman Memorial
Hospital in Los Angeles, is one who
recommends colostrum as a digestive
treatment. "Colostrum has the
greatest components of ingredients
directed toward the digestive tract,"
said Henderson. "Its growth factors
help cells of the digestive tract
redevelop themselves and it also has
immune factors that reestablish the
immunity of the gastrointestinal tract
and kill off bad bacteria that is
overgrown." Colostrum decreases
intestinal permeability and enhances the
assimilation of nutrients.
After years of research, doctors have
found that bovine colostrum provides
similar immune factors as human
colostrum. In fact, bovine colostrum may
be up to 40 times richer in immune
factors, depending on its source and
how it is processed.Immunoglobulins,
lactoferrin, cytokines and interferon are
powerful immune factors found in
colostrum and are key to the
Immunoglobulins are large protein
molecules that comprise more than 40
percent of proteins and are found in the
body's blood serum. There are five
classes of immunoglobulins--each with
its own amino acid structure and function
in the body. These molecules can attach
to, penetrate, destroy or immobilize
specific antigens. Colostrum contains all
five of these molecules and
polyproline-rich-pepetides, which have
been proven to boost an underactive
immune system.A recent study
determined that bovine immunoglobulins
concentrate (BIC)-Clostridium difficile
could pass through the human stomach
and small intestine. The study also found
that since BIC-C difficile could resist
digestion in the human upper
gastrointestinal tract, it could be a useful
non-antibiotic approach to the prevention
and treatment of diarrhea and colitis.
(Gut 1999 Feb; 44(2): 212-7).
Since colostrum can decrease Leaky
Gut Syndrome i.e. intestinal permeability
and enhance the assimilation of
nutrients, using colostrum as a
foundation supplement can enhance the
bioavailability of nutrients and protect the
digestive tract from toxins and
pathogenic invaders. This effect can also
be increased when combined with
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Dr. Alfred E. Fox holds a Ph.D. from Rutgers University in Microbiology (Immunochemistry) and has more than 25
years of senior management experience at Carter-Wallace, Baxter Dade Division and Warner-Lambert, where he
was responsible for research and development and regulatory affairs. He was also the founder and president of two
biotechnology companies focused on agribusiness and environmental monitoring, respectively. For the past 15
years, Dr. Fox has been the President of Fox Associates, a business and technology consulting firm serving
small- to mid-size companies in the human and animal healthcare fields. He focuses primarily on marketing and
regulatory issues and for the past 10 years has continuously consulted to bovine colostrum manufacturers, where
he has gained regulatory approval for their products, been a technical advisor, helped design and develop
marketing strategies and served as an expert witness in legal matters.
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